A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Abramson Cancer Center at Penn Medicine
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients being treated for oropharyngeal cancer with undergoing concurrent chemotherapy and radiation therapy (photons) for a histological diagnosis of squamous cell carcinoma to the head and neck at the University of Pennsylvania
Age at least 18 years old
Treatment entails significant risk for symptomatic mucositis likely to require opioid analgesia, as per the discretion of treating physician/NP
Subjects are capable of giving informed consent
You may not be if
Patients anticipated to receive radiation therapy with Protons
History of hypersensitivity to pregabalin or gabapentin
History of seizure or currently taking anti-epileptic medication
Creatinine clearance of less than 30 mL/min by Cockcroft-Gault estimate
Has another painful condition requiring chronic use of opioid analgesic, gabapentin, or pregabalin
History of serious mood disorder or attempted suicide as determined by patients history and physical and by using theDepression Screening
Subjects with a score of greater than 10 or those answering #5 with scores greater than a "0" will be deemed ineligible to be enrolled on study
History of angioedema
New York Heart Association class III or IV heart failure
Platelets of less than 150 mg/dL or history of thrombocytopenia
The patient has any uncontrolled intercurrent illness including but not limited to psychiatric illness/social situations that would limit compliance or interfere with their ability to participate
Clareo Health | A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck.
