Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Alexion Pharmaceuticals, Inc.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Able to understand and willing to comply with study procedures, restrictions, and requirements, as judged by the Investigator.
Newly established diagnosis of WD by Leipzig-Score ≥ 4 documented by testing as outlined in 2012 European Association for the Study of the Liver Wilson Disease Clinical Practice Guidelines.
NCC levels within or above the normal reference range (0.8 to 2.3 micromole).
Willing to undergo 48 hour washout from current WD treatment
You may not be if
Treatment for greater than 24 months for WD with chelation therapy (for example, penicillamine, trientine hydrochloride) or zinc therapy.
Decompensated hepatic cirrhosis.
Model for End-Stage Liver Disease score \> 11.
Modified Nazer score \> 6.
Gastrointestinal bleed within past 6 months.
Alanine aminotransferase \> 5 x upper limit of normal.
Marked neurological disease requiring either nasogastric feeding or intensive in-patient medical care.
Severe anemia with a hemoglobin \< 9 grams/deciliter.
Clareo Health | Efficacy and Safety Study of WTX101 (ALXN1840) in Adult Wilson Disease Patients
