A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Onychomycosis of the Toenail

Exclusion Criteria

• •Presence of subungual hematoma or melanonychia.
• •Presence of dermatophytoma/nail streaks and severe onychorrhexis.
• •Significant dystrophy or anatomic abnormalities of the great toenail.
• •Presence of any other infections of the foot.
• •Evidence of clinically significant major organ disease.
• •Poorly controlled diabetes mellitus.
• •Onychomycosis involving more than 8 toe nails.
• •Recent use of systemic antifungal therapy.
• •Recent of any topical antifungal nail therapy.
• •Recent use of systemic corticosteroid therapy.
• •Recent use of immunosuppressive medication.
• •History of prolonged QT intervals.
• •Known human immunodeficiency virus (HIV) infection.
• •Known significant renal or hepatic impairment.
• •Known history of intolerance or hypersensitivity to azole antifungal drugs.