PROPHY-VAP: Prevention of Early Ventilation Acquired Pneumonia (VAP) in Brain Injured Patients by a Single Dose of Ceftriaxone

Exclusion Criteria

• •Patient with a high risk of death within the 48 first hours after admission,
• •Patient intubated for more than12 hours
• •Intubation after the 48th hours after admission
• •Coverage to cardiopulmonary arrest
• •Coma due to a tumor, an infectious disease or a cardiac arrest
• •Previous hospitalisation within the last month before admission for coma
• •béta-lactamines allergy
• •Patient who receive already antibiotics at the admission for a previous infection
• •Prophylactic antibiotic due to be done within 24 hours following the randomisation
• •Patient Intubated through a tracheal tube with subglottic secretion aspiration
• •Patient with a tracheotomy
• •Patient or family refuse to be involved in the study
• •Use of Ceftriaxone within 2 days before enrolment
• •Participation in another research protocol focusing on an anti-infective treatment or on a measure decreasing the risk of infection
• •Patients not affiliated to a social security scheme, Pregnant woman or breast-feeding mother, Patients deprived of their liberty by judicial or administrative decision