Follow-up of Early Breast Cancer by Dynamic Evaluation of CEA and CA 15.3 Followed by 18FDG-PET

Inclusion Criteria

• •Male or female ≥18 years.
• •Histologically confirmed stage I-III epithelial breast cancer.
• •Adequate surgery of breast and axilla:
• •1. patients must have undergone either a total mastectomy or breast conserving surgery
• •2. surgical margins of the resected specimen must be histologically free of invasive tumor.
• •Cohort 1: if chemotherapy and/or radiotherapy are indicated the patients must be randomized between 1 month and 2 months from the end of chemotherapy and/or radiotherapy; if only hormonal adjuvant therapy is indicated the patients must be randomized within 3 months from the completion of surgery
• •Cohort 2: patients must be randomized in the trial after 5 years of follow-up without relapse (but within year 6)
• •Signed informed consent obtained prior to any study-specific procedures.