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Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers

Isolation of Genotype-specific Isoforms of Human Vitamin D-binding Protein (DBP/Gc)

NCT02258035•Universitaire Ziekenhuizen KU Leuven

Summary

The purpose of this study is to isolate genotype-specific DBP/Gc from homozygous human volunteers and use these purified proteins to cross-validate existing or novel assays for this serum protein and to evaluate the binding characteristics of these variants of DBP/Gc for different vitamin D metabolites.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Generally healthy adults (≥ 18 years), non pregnant, with known DBP/Gc genotype

Exclusion Criteria

•Inability to provide written informed consent
•No children or pregnant women
•Persons with known abnormal serum proteins

Locations (1)

UZ Leuven

Leuven, Belgium

Key Dates

Start Date

November 1, 2014

Primary Completion Date

December 1, 2016

Completion Date

December 1, 2025

Last Updated

July 3, 2024

Enrollment

ESTIMATED participants

Conditions

Vitamin D Deficiency

Interventions

Blood draw

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 3, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers

Inclusion Criteria

Exclusion Criteria

The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients

Randomized Trial of Enteral Vitamin D Supplementation in Infants < 28 Weeks Gestational Age or <1000 Grams Birth Weight

Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.

Cholecalciferol in Newly Diagnosed Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia With Vitamin D Deficiency

Peripheral Immunological Effects of High-dose Vitamin D Treatment in Healthy Subjects

Daily Vitamin D for Sickle-cell Respiratory Complications