Age over 18 years.

First metastatic breast cancer relapse after treatment for early stage disease

A minimum of 10 evaluable lesions in the liver on routine x-ray CT imaging

Patient prescribed cytotoxic, endocrine or biological therapies

Patient physically and psychologically fit enough to consider sequential WB-- - DWI imaging alongside their standard disease monitoring

Written informed consent

Evolution of Resistance to Systemic Therapies in Patients With Breast Cancer