Positive Airway Pressure Therapy Study in Sleep Apnea and Diastolic Heart Failure

Inclusion Criteria

• •Clinical signs and symptoms of heart failure according to the ESC guidelines
• •Echocardiographic evidence of a preserved systolic left ventricular function (echocardiographic left ventricular ejection fraction \> 50%)
• •Polysomnographic evidence of at least moderate sleep-disordered breathing: apnea-hypopnea index (AHI) \> 15 / h with ≥ 50% central events and with with a central AHI of ≥ 10/h (AHI based on total sleeping time, TST)
• •BNP or NT-pro BNP ≥ 300 pg / ml
• •NYHA class II or III
• •Patient tolerates the ventilation treatment (1h sample ventilation)
• •Stable drug therapy in the last 4 weeks prior to randomization (no iv diuretic therapy or increasing the dose of diuretics to ≥ 100%)
• •Minimum age of patients of 18 years
• •patient willing to undergo study procedures
• •signed informed consent