Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
VA Office of Research and Development
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18 years old;
Ability to give informed consent;
Life expectancy greater than 6 months;
Estimated GFR 30-59 ml/min/1.73m\^2;
Overweight (BMI \>=25 to \< 30 kg/m\^2) or obese (BMI \>=30 kg/m\^2); or normal (BMI \>=18.5 to \<25 kg/m\^2) if pre-diabetic or insulin resistant.
You may not be if
Pregnancy or breast feeding;
Presence or history of Diabetes Mellitus type I or II
History of metformin use or any insulin sensitizer or any drug for the treatment of metabolic syndrome over the last one year;
Any acute kidney injury episode in the last 4 months due to the risk of recurrent AKI;
Proteinuria of \> 5 g in 24 hours determined by a 24 hour urine collection or PCR \> 4.5;
Uncontrolled hypertension with systolic blood pressure 160 mmHg and diastolic blood pressure 100 mmHg;
Patients with new changes to their antihypertensive regimen over the last 1 month;
Severe, unstable, or active inflammatory disease; active infection including seropositive HIV, Hepatitis B or C; active connective tissue disorder; or moderate to severe liver disease;
Decompensated heart failure;
Recent hospitalization or surgical procedure within 1 month prior to the study for any cause;
Current active malignancy or cancer history in the prior 5 years (excluding squamous cell and basal cell skin cancers);
Known intolerance to the study drug;
Patient receiving oral or injected steroids
Use of any investigational product or device within 30 days prior to screening, or requirement for any investigational agent prior to completion of all scheduled study assessments;
