Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Children's Hospital Medical Center, Cincinnati
This study will address the working hypothesis that intravenous lidocaine may be administered as a bolus followed by an infusion with reliable and safe blood levels of lidocaine. Serial blood draws will be obtained to determine safety of lidocaine doses used in this study by measuring blood levels of lidocaine and its metabolites.
Age
3–15
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
male or female children 3-15 years of age
ASA physical status 1-3
scheduled for colorectal surgery with abdominal incision
You may not be if
ASA physical status \> 3
postoperative intubation planned ahead of surgery
history of chronic use of opioid (use longer than 3 months)
history of hepatic, renal, or cardiac failure
history of significant liver disease including liver failure, acute or chronic hepatitis, hepatomegaly, portal hypertension and elevated liver enzymes
history of organ transplant
BMI \> 30
history of cardiac arrhythmia
history of long QT syndrome
history of allergic reaction to lidocaine or similar agents
history of seizure disorder
patient without PICC or other central access with contraindication to inhalation induction
family history or known patient susceptibility to malignant hyperthermia
