Perioperative Pregabalin and Lidocaine to Reduce Chronic Breast Cancer Pain

Exclusion Criteria

• •previous breast surgery within six months of index surgery
• •undergoing a DIEP (Deep Inferior Epigastric Perforator) flap procedure
• •patient has chronic pain or a chronic pain syndrome for which they have taken 4 or more daily medications (i.e. opioids, anti-convulsants, anti-spasmodic, anti-depressants, anti-inflammatories) or routine pain intervention (i.e. nerve blocks) during the past 3 months
• •documented hypersensitivity or allergy to pregabalin, gabapentin, or lidocaine
• •history of ventricular tachycardia, ventricular fibrillation, or atrioventricular block ≥ type II
• •history of congestive heart failure
• •renal insufficiency with creatinine \> 120 µmol/L
• •known or previously documented cirrhosis
• •pregnant
• •unable to swallow study medications
• •patient's surgeon believes patient is inappropriate for inclusion in trial
• •unlikely to comply with follow-up (e.g. no fixed address, plans to move out of town)
• •language difficulties that would impede valid completion of questionnaires
• •patient requires gabapentin or pregabalin for a medical condition or has been taking gabapentin or pregabalin daily during the past 1 week