Efficacy and Safety Study of CVT-301 In Parkinson's Disease Patients With OFF Episodes

Inclusion Criteria

• •Idiopathic Parkinson's Disease (PD) diagnosed between the ages of 30 and 85 years;
• •Hoehn and Yahr Stage 1-3 in an "on" state;
• •Require levodopa-containing medication regimen at least 3 times during the waking day;
• •Experience motor fluctuations with a minimum of 2 hours of average daily "off" time per waking day (excluding early morning "off" time) and demonstrate levodopa responsiveness;
• •Are on stable PD medication regimen;
• •Total daily LD dose \<1600 mg/day;
• •Able to perform a spirometry maneuver in the ON and OFF states;
• •Normal cognition confirmed by MMSE score ≥25