Lead Sponsor

Vapotherm, Inc.

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Adult patients (\> 18 yrs of age)
•Presentation with acute respiratory failure according to the following criteria:
•If any of these are present: Respiratory Rate \>22 or labored; Suspected Acute Respiratory Acidosis, as defined as pH \<7.32 on initial blood gas(either arterial or venous); Hypoxemia, as defined as Pulse Ox \<92%;
•Clinical decision to escalate therapy to non-invasive ventilatory support, or to maintain non-invasive ventilatory support if delivered to the ED on such.

•Suspected drug overdose
•Cardiovascular instability as demonstrated by hypotension relative to initial clinical presentation that requires immediate intervention
•End stage cancer
•Life expectancy \< 6 months
•Respiratory arrest or significant respiratory depression on presentation
•Glasgow Coma Scale score \< 9
•Cardiac arrest on initial presentation
•Need for emergent intubation
•Known or suspected cerebrovascular accident
•Known or suspected ST segment elevation myocardial infarction
•Patients with increased risk of pulmonary aspiration
•Agitation or uncooperativeness