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COMPLETEDPhase 2NCT02236195

Study of Mocetinostat in Patients With Urothelial Carcinoma Having Inactivating Alterations of Specific Genes

Mocetinostat is an orally administered histone deacetylase (HDAC) inhibitor. This study is a Phase 2 trial evaluating the efficacy of mocetinostat in patients that have advanced urothelial carcinoma t...

Lead sponsor: Mirati Therapeutics Inc.•14 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Mirati Therapeutics Inc.

To be eligible for this study, patient tumor testing must demonstrate a genetic alteration resulting in the loss of function of the Histone Acetyltransferase (HAT) family genes, CREBBP and/or EP300, including gene deletions or selected inactivating mutations. If testing has not already been performed, the study will provide for the testing.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Diagnosis of urothelial carcinoma
•Metastatic or locally advanced disease
•Prior chemotherapy that included a platinum agent
•Test results showing genetic change in tumor gene for CREBBP and/or EP300
•At least one tumor that can be measured

Exclusion Criteria

•Uncontrolled tumor in the brain
•Impaired heart function

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 1, 2017Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2

Enrollment17

Start dateOct 2014

Last updatedSep 1, 2017

Condition

Urothelial Carcinoma

Locations shown

University of Alabama

Birmingham, Alabama

City of Hope National Medical Center

Duarte, California

Florida Cancer Specialists

Fort Myers, Florida

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 1, 2017Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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