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Lead
Seoul National University Hospital
With
Ministry of Food and Drug Safety, Korea
Children with tubular proteinuria (urine protein to creatinine ratio \> 0.3 mg/mg) were randomly assigned in 1:1 ratio to losartan or placebo treatment for 12 weeks, then crossed over to the opposite intervention for another three months after a washout period of 2 weeks. The primary outcome is the change in urinary protein-creatinine ratio from baseline to the end of 12 weeks. Efficacy of losartan in children with CKD with tubular proteinuria was also investigated with additional retrospective review of medical record.
Age
2–18
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age: 2years or older and younger than 18 years
estimated GFR ≥ 30mL/min/m\^2
Mean urinary protein-creatinine ratio \> 0.3 g/g from three first-morning spot urine collections