Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones

Exclusion Criteria

• •Suspicious of pseudarthrosis focus infection diagnosed by clinical inspection and blood analysis.
• •Positive serology for HIV (Anti-HIV I/II-Ac), Hepatitis B (HBsAg, HBcAc), Hepatitis C (Anti-HCV-Ac) or Syphilis Lúes (TP-Ac).
• •Significant abnormal laboratory tests that contraindicates patient's participation in the study.
• •Pregnant woman or without proper anticonceptive measures according to the investigator, or breath feeding
• •Smoker of more than 15 cigarettes a day
• •Congenital disorders of bones (hypophosphatemia), bone metabolic disorders associated to primary or secondary hypoparathyroidism.
• •Badly managed diabetes mellitus.
• •Patients diagnosed with peripheral arterial disorders
• •Previous therapeutic radiation (5 previous years) of the affected bone.
• •Neoplasia within the previous 5 years, or without remission
• •The patient is legally dependent
• •Participation in another clinical trial or treated with an investigational medicinal product the previous 30 days
• •Other pathologic conditions or circumstances that difficult participation in the study according to medical criteria
• •The patient does not accept to be followed-up for a period that could exceed the clinical trial length