Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ardea Biosciences, Inc.
Age
18–85
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Subject has a body weight ≥ 50 kg (110 lbs.) and a body mass index ≥ 18 and ≤ 40 kg/m2.
Subject with renal impairment, as determined at Screening, with creatinine clearance as calculated by the Cockcroft-Gault formula of 60 to \< 90 mL/min (mild impairment), 30 to \< 60 mL/min (moderate impairment), or 15 to \< 30 mL/min (severe impairment), or a matched control subject (by age and body mass index) with a creatinine clearance of ≥ 90 mL/min.
Subject has a Screening serum urate level ≥ 4.5 mg/dL and ≤ 10 mg/dL
You may not be if
Subject has a history or clinical manifestations of significant metabolic, hematological, pulmonary, cardiovascular, gastrointestinal, neurologic, hepatic, renal, urological, or psychiatric disorders.
Subject has a history or suspicion of kidney stones.
Subject has a history of asthma.
Subject has undergone major surgery within 3 months prior to Day 1.
Subject has donated blood or experienced significant blood loss (\> 450 mL) within 12 weeks prior to Day 1 or gave a plasma donation
Clareo Health | Mild, Moderate and Severe Renal Impairment Study
