Controlled Acute Hypoxia Study - Abbreviated Sensor Line

Exclusion Criteria

• •Under 18 years or over 50 years of age
• •Pregnant and/or lactating women
• •Hypertension: on three consecutive readings, systolic pressure greater than 145 mm Hg or diastolic pressure greater than 90 mm Hg
• •Premature ventricular contractions (PVCs) that are symptomatic or occur at a rate of more than four per minute
• •History of seizures (except childhood febrile seizures) or epilepsy
• •History of unexplained syncope
• •Daily or more frequent use of anxiolytic drugs (benzodiazepines) for treatment of anxiety disorder
• •Recent history of frequent migraine headaches: average of two or more per month over the last year
• •Compromised circulation, injury, or physical malformation of fingers, toes, hands, ears or forehead/skull or other sensor sites which would limit the ability to test site needed for the study. (Note: Certain malformations may still allow subjects to participate if the condition is noted and would not affect the particular sites utilized.)
• •History of acute altitude sickness at or below moderate elevation (up to 5,000-10,000 feet) defined as three or more of the following symptoms: moderate to severe headache, general malaise, dizziness/lightheadedness, nausea/vomiting, fatigue/weakness, shortness of breath, nosebleed, persistent rapid pulse, or peripheral edema
• •History of significant respiratory disease such as severe asthma or emphysema
• •Sickle cell disease or trait
• •Clinically significant abnormal finding on medical history, physical examination, clinical laboratory test or ECG. Clinical significance will be assessed by the principal investigator or study physician as designated.
• •History of stroke, transient ischemic attack or carotid artery disease
• •History of myocardial ischemia, angina, myocardial infarction, congestive heart failure or cardiomyopathy
• •History of chronic renal impairment
• •Severe contact allergies to standard adhesives, latex or other materials found in pulse oximetry sensors, ECG electrodes, respiration monitor electrodes or other medical sensors
• •Unwillingness or inability to remove colored nail polish from test digit(s)
• •Unwillingness or inability to give informed consent
• •Prior or known allergies to: lidocaine (or similar pharmacological agents, e.g., Novocain) or heparin
• •Recent arterial cannulation (i.e., less than 30 days prior to study date)
• •Six or more arterial cannulations of each (right \& left) radial artery
• •History of clinically significant complications from previous arterial cannulation
• •Current use of blood thinners: prescription or daily aspirin use