Improving the Safety of Oral Immunotherapy for Cow's Milk Allergy

Exclusion Criteria

• •1. Required previous admission to an intensive care unit for management of an allergic reaction.
• •2. Significant symptoms of non---IgE---mediated CM allergy within the previous 12 months.
• •3. Children with a past history of CM allergy currently consuming CM-containing products other than extensively--heated milk in baked foods (e.g. biscuits, cakes).
• •4. Poorly controlled asthma within the previous 3 months (as defined by clinician judgement with reference to the ICON consensus), or asthma requiring treatment with \>5 days oral corticosteroids within the previous 3 months.
• •6. Clinically significant chronic illness (other than asthma, rhinitis or eczema)
• •7. History of symptoms of eosinophilic oesophagitis, irrespective of cause
• •8. Undergoing specific immunotherapy to another allergen and within the first year of treatment.
• •9. Receiving anti--IgE therapy, oral immunosuppressants, beta---blocker or ACE inhibitor.
• •10. Pregnancy
• •11. Unwilling or unable to fulfil study requirements