Intraoperative Radiotherapy for Korean Patients With Breast Cancer

Exclusion Criteria

• •Pregnancy or unwillingness to use a reliable contraceptive method in women of child-bearing potential.
• •Patients who received prior chemotherapy or radiotherapy for breast cancer
• •Patients who have history of cancer other than in situ uterine cervix cancer or non-melanoma skin cancer
• •The depth of tumor from skin measured by ultrasonography is less than 1cm.
• •Contraindications to breast conservative surgery
• •* Multicentric breast cancer (tumors in more than one quadrant)
• •* Diffuse malignant appearing microcalcification
• •* Prior therapeutic radiation to the breast region
• •* Small breast, which is not possible to achieve clear margins in relation to a cosmetically acceptable result
• •* History of collagen vascular disease, such as active scleroderma and active lupus
• •Postoperative exclusion
• •* Patients who require re-excision due to positive resection margin
• •* The depth of cavity from skin after lumpectomy is less than 0.5cm