Dapagliflozin in Type 1 Diabetes

Exclusion Criteria

• •insufficient venous status on both forearms
• •renal and/or hepatic insufficiency (including microalbuminuria and/or albumin/creatinin-ratio)
• •history of cancer
• •intake of medication and/or substances capable to influence insulin sensitivity within the last 3 months prior to study inclusion
• •alcohol- and/or drug abuse, nicotine consumption \> 5 cigarettes / 24h
• •brittle-diabetes
• •history of severe hypoglycemia, defined as the need for foreign assistance independent of actual blood glucose concentration measured
• •history or evidence of any other clinically significant disorder, condition or disease other than those outlined above that, in the opinion of the investigator may compromise the ability of the participant to give written informed consent, would pose a risk to subject safety, or interfere with the study evaluation, procedures or completion.