Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Michigan
With
Crohn's and Colitis Foundation
Subjects are randomized to low or high dose vitamin D, and outcomes including steroid prescriptions, CD-related hospitalizations, CD-related surgeries, and the modified Harvey-Bradshaw Index are measured.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of CD
Age \>= 18 and \<75
Vitamin D deficiency or insufficiency (serum 25-hydroxyvitamin D \< 30ng/ml)
You may not be if
Corticosteroid use in the last 4 weeks
CD-related surgery in the last 6 months
CD-related hospitalization in the last 4 weeks
Pregnancy, intended pregnancy during the study period or nursing
Serum calcium \>10.2 mg/dL
History of primary sclerosing cholangitis
History of undergoing an ileal pouch-anal anastomosis
Current active perianal disease
History of nephrolithiasis in the past 2 years
Anticipated change in therapy in the next 30 days (steroids, biologic initiation)
modified Harvey-Bradshaw Index of 10 or more
History of decreased renal function (glomerular filtration rate \<30ml/min based on MDRD) or polycystic kidney disease
History of sarcoidosis
History of hyperparathyroidism
Any other chronic condition that may preclude high doses of Vitamin D such as lymphoma
Concurrent use of hydrochlorothiazide, phenytoin, phenobarbital, carbamazepine or primidone
