Nilotinib ± Peg-IFN for First Line Chronic Phase CML Patients

Exclusion Criteria

• •Contra-indication to IFN
• •Transcripts other than M-Bcr
• •Pregnancy, lactation
• •HIV positivity, chronic hepatitis B or C.
• •Prior or concurrent malignancy other than CML (exceptions to be mentioned)
• •History of arterial occlusive disease or (peripheral, carotids or severe coronary heart disease).
• •Permanent elevation of total cholesterol and triglycerides despite treatment
• •Severe psychiatric/neurological disease (previous or ongoing)
• •Concomitant auto-immune disease
• •Other investigational product ongoing
• •Ongoing immunosuppressive treatment
• •Ongoing treatment at risk for inducing torsades de pointes
• •QTcF \> 450ms despite correction of predisposing factors (i.e electrolytes…)
• •Congenital long QTcF
• •Unstabilised thyroid disorder
• •No health insurance coverage