Impossibility to obtain a valid informed consent

Patients unable to undergo MR imaging, including those with contra-indications

Contra-indications to MR guided focal laser therapy (colitis ulcerosa, rectal pathology or abdomino perineal resection)

Metallic hip implant or any other metallic implant or device that distorts local magnetic field and compromises the quality of MR imaging

Patients with evidence for nodal or metastatic disease

Patients with an estimated Glomerular Filtration Ratio (eGFR) \< 40 mL/min/1.73 m2

MR-guided Focal Laser Ablation of the Prostate