Improving Glycaemic Control With L-carnitine

Exclusion Criteria

• •Malignancy (excluding localised basal and squamous cell skin cancer)
• •Metabolic diseases (stable treated hypothyroidism allowed)
• •Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
• •Primary muscle disorders
• •Cerebrovascular disease
• •Neurological disease e.g. epilepsy, Parkinsons disease
• •Active respiratory disease
• •Active gastrointestinal or liver disease
• •Renal impairment (eGFR \<60 ml/min)
• •Clotting dysfunction
• •Anti-diabetes medication other than metformin
• •Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
• •Any other conditions in addition to the above that the investigators consider may affect study measurements or safety