Efficacy, Safety And Tolerability Of PF-06743649 In Gout Subjects.

Exclusion Criteria

• •Positive medical history or current evidence of medical or psychiatric condition/disease, or ECG or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the subject inappropriate for entry into this study.
• •Chronic kidney disease classified as moderate or severe (Clinical Practice Guideline, National Kidney Foundation)12; with GFR \< 60 mL/min/1.73m2 calculated by the Cockcroft-Gault equation.
• •Subjects with current tophaceous gout.
• •Gout flare that has not resolved for at least 2 weeks prior to randomization.