Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes

Inclusion Criteria

• •1. Able to read, understand, and willing to sign an Informed Consent Form (ICF) and complete questionnaires written in English.
• •2. Generally healthy males or females, 21 years of age or older at Screening.
• •3. Able to meet cohort-specific requirements as follows:
• •Cohort 1 - Leading U.S. tobacco-burning non-menthol cigarette, and
• •Cohort 2 - Leading U.S. tobacco-burning menthol cigarette:
• •* self-reports at the Screening Visit smoking at least 5 cigarettes per day and inhaling the smoke, for at least 3 months prior to Screening
• •* self-reports smoking Leading U.S. tobacco-burning non-menthol cigarette or Leading U.S. tobacco-burning menthol cigarette as usual brand (UB) cigarettes \[UB cigarette is defined as the cigarette brand style currently smoked most frequently by the participant\];
• •Cohort 3 - Electronic cigarette #1 smokers, and
• •Cohort 4 - Electronic cigarette #2 smokers:
• •* self-reports at the Screening Visit smoking a non-menthol e-cigarette at least once per day, for at least 3 months prior to Screening;
• •* willing to switch from using their current e-cigarette brand style to using a different e-cigarette brand style during the study;
• •Cohort 5 - Electronic cigarette #3 smokers:
• •* self-reports at the Screening Visit smoking a menthol e-cigarette at least once per day, for at least 3 months prior to Screening;
• •* willing to switch from using their current e-cigarette brand style to using a different e-cigarette brand style during the study;
• •Cohort 6 - U.S Market-sample electronic cigarette smokers:
• •* self-reports at the Screening Visit smoking the selected U.S. market-sample e-cigarettes (menthol or non-menthol) at least once per day, for at least three months prior to Screening;
• •* willing to continue exclusive use of their preferred style (flavor) of e-cigarette during the study.
• •4. Females of childbearing potential must be willing to use a form of contraception acceptable to the Investigator from the time of signing informed consent until study discharge or be surgically sterile for at least 90 days prior to enrollment;
• •5. Able to safely perform the required study procedures, as determined by the Investigator.