Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint

Exclusion Criteria

• •Alzheimer's disease or other dementia,
• •Parkinson's disease treated,
• •Epilepsy treated,
• •Huntington's disease,
• •Brain tumor,
• •History of a progressive disease which may have consequences for the central nervous system (blood pressure, higher or equal to 180/100 mmHg, chronic pulmonary disease with hypoxia; cerebrovascular accident of less than 3 months, cranial traumatism with persistent neurologic deficit, subdural hematoma, brain surgery),
• •Antecedent of alcoholism or chronic drug-addiction with an obvious or documented consequence on cognition,
• •Severe depression : score Montgomery Asberg Depression Rating Scale (MADRS) \> 18,
• •Psychotropic drug therapy (at the discretion of the clinician),
• •Hypercalcaemia or treatment for a hypercalcaemia,
• •Known hypersensitivity to the vitamin D,
• •Granulomatous disease,
• •Treatment of vit D at doses higher than the current recommendations,
• •History of calcium urinary lithiasis of less than 1 year,
• •Nonsteroidal antiinflammatory drug (NSAID) chronic treatment,
• •Severe medical or surgical affection of less than 3 months,
• •Unstable health, severe hepatic or renal deficiency,
• •Deprivation of liberty, under judicial protection,
• •Institutionalization (EHPAD),
• •Illiteracy,
• •Participation in another biomedical research. A diagnosis of MCI (Mild Cognitive Impairment) of less than 6 months is not a criterion of non-inclusion.