Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Boehringer Ingelheim
Age
18–40
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or female patients with a diagnosis of asthma according to the American Thoracic Society (ATS) presenting at the emergency room with an acute moderate and/or severe asthma attack
Patients aged between18 to 40 years
Patients able to perform spirometry (PEFR and FEV1)
PEFR \< 60% and \> 25 % of predicted normal value or a FEV1 \<= 60% of predicted normal value
Patients able to sign witnessed informed consent
You may not be if
Patients with very severe or life threatening obstruction, manifested by:
* Cyanosis of tongue and lips
* Confusion, drowsiness, coma or exhaustion
* Silent chest on auscultation or weak respiratory effort
* PEFR \< 25% the predicted normal value
* Bradycardia (of less 60 beats/min)
Patients with a smoking history of more than 10 pack/years
Patients with chronic obstructive pulmonary disease (COPD)
Patients on treatment for or suspected as having glaucoma
Patients with uncontrolled hypertension
Patients with known allergy or contra-indications to either salbutamol, ipratropium or hydrocortisone or their excipients
Female patients known or suspected to be pregnant or nursing
Patients known or suspected on clinical grounds to have pneumonia, pneumothorax or pneumomediastinum
Patients with a history of chest surgery
Patients with other respiratory conditions if diagnosed. These included pulmonary fibrosis, bronchiectasis, cystic fibrosis, pulmonary tuberculosis, pulmonary complications of AIDS, lung cancer
Patients requiring drugs for the treatment of the acute asthma attack other than the study drug, hydrocortisone or oxygen
Patients who have previously recruited into this study
Patients who have been on other investigational drugs within three months prior to study entry
Patients with acute myocardial infarction, pulmonary edema or other life threatening disease, which in the judgment of the ER (Emergency room) physician precluded entry into the study
Patients with obvious or previous diagnosed serious hepatic or renal impairment or bladder neck obstruction
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