Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases

Inclusion Criteria

• •Patients with synovial sarcoma confirmed by MSKCC pathological review
• •Patients with single or multiple lung metastases at diagnosis or that develop over the course of treatment. After completion of all chemotherapy, lung metastases or must be ≤ 2cm.
• •Age ≥12 months of age
• •Karnofsky performance status (KPS) must be ≥ 70 for patients ≥ 16 years of age and Lansky performance status must be ≥ 70 for patients \< 16 years of age.
• •Normal cardiac function
• •No active coronary artery disease;
• •No New York Heart Association class II, III or IV disease;
• •No arrhythmia requiring treatment.
• •Baseline echocardiogram with a shortening fraction of ≥27% or an ejection fraction ≥ 50%.
• •Female patients of childbearing potential must have a negative pregnancy test within 14 days of radiation start.
• •Female patients who are lactating must agree to stop breast-feeding.
• •Sexually active patients of childbearing potential must agree to use effective contraception.