VEGF and PEDF in Patients With Myopic Choroidal Neovascularization

Effect of Intravitreal Ranibizumab Injection on Aqueous Humor Concentrations of Vascular Endothelial Growth Factor and Pigment Epithelium-derived Factor in Patients With Myopic Choroidal Neovascularization.

NCT02175940•Università degli Studi di Brescia

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Summary

This was a prospective, case-control study investigating aqueous levels of VEGF and PEDF in eyes with mCNV treated with IVB.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•pathologic myopia, defined as spherical equivalent \>6 diopters and axial length \>26 mm
•posterior pole myopic retinal changes (posterior staphyloma, chorioretinal atrophy, papillary crescent);
•fluorescein angiography, indocyanine green angiography and optical coherence tomography detection of the subfoveal or juxtafoveal choroidal neovascularization
•clear ocular media;

Exclusion Criteria

•previous treatment for choroidal neovascularization, including the previous intravitreal drug injection or PDT
•presence of other maculopathy as diabetic retinopathy or retinal vascular occlusion
•history of recent myocardial infarction or other thromboembolic events
•ongoing uncontrolled hypertension or glaucoma
•refractive media opacities
•previous eye surgery

Locations (1)

Medical Retina Department, University of Molise

Cambpobasso, CB, Italy

Key Dates

Start Date

July 1, 2013

Primary Completion Date

January 1, 2014

Completion Date

May 1, 2014

Last Updated

June 26, 2014

Enrollment

ACTUAL participants

Conditions

Myopic Choroidal NeovascularizationVEGF Aqueous LevelPEDF Aqueous Level

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UNKNOWNPHASE4

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 26, 2014Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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