The Tolerability and Effect of Food on the Pharmacokinetics of a Single 800 mg Oral Dose of BIA 2-093

Inclusion Criteria

• •Male subjects aged between 18 and 45 years, inclusive.
• •Subjects of body mass index (BMI) between 19 and 28 kg/m2, inclusive.
• •Subjects who were healthy as determined by pre study medical history, physical examination, neurological examination, EEG, and 12-lead ECG.
• •Subjects who had clinical laboratory tests clinically acceptable to the investigator.
• •Subjects who were negative for HBsAg, anti-HCV Ab and HIV-1 and HIV-2 Ab tests at screening.
• •Subjects who were negative for alcohol and drugs of abuse at screening and admission.
• •Subjects who were non-smokers or who smoked less than 10 cigarettes or equivalent per day.
• •Subjects who were able and willing to give written informed consent.
• •Subjects who had a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, haematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, connective tissue diseases or disorders.
• •Subjects who had a clinically relevant surgical history.
• +17 more criteria