Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Cancer Trials Ireland
With
Janssen, LP
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Provision of written informed consent prior to any study related procedures
Males aged 18 years or older
ECOG performance status of less than or equal to 1
Life expectancy of 10 years or more (using MSKCC nomogram)
Pathological proven prostate carcinoma at intermediate to high risk of recurrence as defined by RTOG
Clinically negative lymph nodes as established by imaging (pelvic CT / MRI), nodal sampling, or dissection within 60 days prior to registration, except patients with lymph nodes equivocal or questionable by imaging are eligible without biopsy if the nodes are less than or equal to 1.5cm; any node larger than this ion imaging will require negative biopsy for eligibility
No evidence of bone metastases on bone scan within 60 days prior to registration. Equivocal bone scan findings are allowed if plain film x-rays are negative for metastasis.
Clinical laboratory values during screening:
* Haemoglobin greater than or equal to 10.0g/dl
* Absolute neutrophil count (ANC) ≥ 1.8 × 10 to the power of 9/L
* Platelets ≥ 100 × 10 to the power of 9/L
Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 95 mmHg \[Note: medically controlled hypertension is permitted\]
Prostate gland size measurable by trans-rectal ultrasound (TRUS) and at least greater than or equal to 30 cm cubed at baseline
Patient is willing to use barrier-method of contraception along with another effective contraceptive method if engaged in sexual activity with a pregnant woman or a woman of child-bearing potential (until 1 week after completing treatment)
You may not be if
Prior treatment for prostate carcinoma, including prostatectomy; high intensity focused ultrasound or cryotherapy; hormonal manipulation (any modalities) including LHRH agonist, anti-androgen, or bilateral orchidectomy; prior or concomitant chemotherapy for prostate cancer; prior radiotherapy including brachytherapy to the region of study cancer; radical local treatment \[Exception: Transuretheral Resection of the Prostate (TRUP) / TRUS is allowed\]
Use of urethral catheter
History of cardiovascular disease; Uncontrolled hypertension \[hypertension controlled by anti-hypertensive therapy is permitted\], clinically significant heart disease as evidenced by myocardial infarction, or arterial thrombotic events in the past 6 months, severe or unstable angina, or New York Heart Association Class III or IV heart failure, or Class II to IV heart failure of cardiac ejection fraction measurement of \<50%
Active or symptomatic viral hepatitis or chronic liver disease
Major thoracic or abdominal surgery or significant traumatic injury within 4 weeks prior to registration, or planned surgery during study participation / within 4 weeks from end of treatment \[Note: patients with planned surgical procedures to be conducted under local anaesthesia are not excluded from the study\]
Gastrointestinal disorder interfering with study drug absorption
Active or uncontrolled disease that may require oral corticosteroid therapy
Positive serology for hepatitis B surface antigen or hepatitis C antibody
Known allergies, hypersensitivity or intolerance to abiraterone acetate, prednisolone, GnRH agonists or their excipients
Contraindications to the use of prednisolone or GnRH agonists per local prescribing information
Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study
Any condition that, in the opinion of the investigator, would compromise the well-being of the patient or that could prevent, limit, or confound the protocol-specified assessments
The patient has or had othe co-existing malignancies within the past 5 years, other than resected non-melanoma skin cancer
Treatment with non-approved or investigational drug within 30 days before the first planned dose of study drug
Clareo Health | Neo-adjuvant Abiraterone Prostate Study
