Medication Development in Alcoholism: Investigating PPAR Agonists

Inclusion Criteria

• •Male or female volunteers, 18-65 years of age
• •Meets DSM-V criteria for Alcohol Use Disorder ≥ moderate severity and DSM-IV criteria for current alcohol dependence
• •Subjects will not be seeking treatment because the medication studies are not treatment trials
• •Subjects must be abstinent a minimum of 3 days (but not more than 7 days) prior to the human lab session
• •Negative BAC and a CIWA score of \< 9 at screening and time of lab session to eliminate acute alcohol or withdrawal effects on dependent measures
• •In acceptable health in the judgment of the study physician, on the basis of interview, medical history, physical exam, ECG, urine test and lab tests
• •Females with childbearing potential must have a negative serum pregnancy test on the screening visit with a negative urine pregnancy test at randomization and agree to use an effective method of birth control for the study duration and two weeks thereafter.
• •Subjects must be able to complete and understand questionnaires and study procedures in English and sign an informed consent
• •Willingness to comply with the provisions of the protocol and take daily oral medication