Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Centre Hospitalier Universitaire Dijon
The research will take place in 3 phases:
PHASE 1 :
30 healthy volunteers will be included to test tolerance to personalized exercise on an eccentric cycle ergometer.
PHASE 2 :
15 patients suffering from coronary artery disease (CAD) and 15 patients suffering from chronic obstructive pulmonary disease (COPD) will be included to test the same protocol.
PHASE 3 :
A total of 169 patients split into 2 parallel groups will be included: a group receiving conventional rehabilitation (group A) and the other group receiving eccentric exercise combined to conventional rehabilitation (group B).
Coronary patients: 93 patients will be included (62 patients in group A and 31 in group B).
COPD patients: 76 patients will be included (38 patients per group).
Age
40–75
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Persons who have provided written informed consent
Healthy volunteers:
Men or women aged between 40 and 75 years.
Patients with CAD:
Men or women aged between 40 and 75 years, with coronary artery disease without heart failure referred for a rehabilitation program.
Left ventricular ejection fraction on echocardiography (Simpson methode) \> 45 %
Patients with Chronic obstructive pulmonary disease:
Men or women aged between 40 and 75 years
Severe Chronic obstructive pulmonary disease (post-bronchodilatator FEV1/FVC \< 0.70 and FEV1 ≤ 60% of predicted value)
Patient not on oxygen therapy (24h/24)
You may not be if
Person without national health insurance cover
Severe, obstructive cardiopathy
Severe aortic valve stenosis,
Severe progressive heart rhythm or conduction disorders not corrected by a pacemaker and detected during the initial effort test
Cardiac intracavitary thrombus,
Severe pulmonary artery hypertension (PAHT systolic \>70mmHg),
Recent history of venous thromboembolism (previous 3 months),
Impaired executive functions making it impossible to understand and adhere to a rehabilitation program (Mini Mental Test \< 24),
Heart transplant,
Associated medical condition that could substantially affect functional capacities (examples: non-stabilized metabolic disorders such as progressive renal insufficiency, major asthenia linked to a severe non-stabilized disorder such as neoplasia, systemic disease…).
Physical incapacity of the lower limbs that could impair rehabilitation, whether they are neurological (central or peripheral), arterial (in particular, peripheral artery disease with a systolic index \< 0.6) or orthopedic (degenerative or inflammatory rheumatism).
Patients who have taken part (within the previous 6 months) or a currently taking part in a rehabilitation program.
Clareo Health | Evaluation of the Effects of Eccentric Training on a Cycle Ergometer, Versus Conventional Concentric Training
