Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Dr. Denis O'Donnell
With
Canadian Institutes of Health Research (CIHR)
Ottawa Hospital Research Institute
University of British Columbia
McGill University
Age
40–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Stable patients with GOLD grade 1 mild COPD will be included in the study if they have: a post-bronchodilator FEV1≥80 %predicted and an FEV1/FVC ratio \<0.7 and \<LLN; ≥40 years of age; and a cigarette smoking history ≥10 pack-years or ≥10 years of exposure to other inhaled substances (i.e., second hand smoke and/or biomass). Symptomatic (category B) subjects will have a Baseline Dyspnea Index (BDI) total score ≤9, a modified Medical Research Council (MRC) dyspnea score ≥2, or a COPD Assessment Test (CAT) score ≥10. Asymptomatic (category A) subjects will have a BDI\>9, modified MRC\<2 or CAT\<10, no history of seeking medical care for respiratory symptoms, and no history of using respiratory medications. Symptomatic current or ex-smokers (\>10 pack-year history) who do not meet criteria for COPD (e.g., post-bronchodilator FEV1\<80%predicted and FEV1/FVC\<0.7, with both measurements also \<LLN) and who are on no respiratory medication will be included. Symptomatic will be defined as: BDI≤9, modified MRC≥2 or CAT\>10. Healthy, age- and sex-matched, non-smoking (\<2 pack-year history) participants with normal spirometry will be used for comparison purposes.
You may not be if
presence of clinically significant comorbidities that could contribute to dyspnea or exercise limitation (i.e., unstable heart disease, a pulmonary disease other than COPD, uncontrolled diabetes, neuromuscular or orthopedic impairment);
