Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer

Exclusion Criteria

• •Previous radiotherapy to the pelvic region
• •Patients in whom induction chemotherapy has been delivered prior to chemo- radiotherapy
• •History of inflammatory bowel disease
• •Previous hip replacement
• •Previous bowel surgery (excluding procedures/operations which would not result in small bowel adhesions - at the discretion of the Principal Investigator)
• •Patients with other syndromes/conditions associated with increased radiosensitivity
• •Any other co-existing malignancies within the past 5 years other than non- melanoma skin cancer
• •Pregnancy or lactation at the time of proposed randomisation
• •Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study or if it is felt by the research / medical team that the patient may not be able to comply with the protocol