Diagnosis of asthma requiring Global Initiative for Asthma (GINA) Step 3 (www.ginasthma.org)or higher treatment

FEV1 \<80% of predicted.

Clinically significant confounding symptoms of allergy to seasonal allergens during the final evaluation period.

Significant symptoms of another clinically relevant illness that is likely to affect scoring of rhinoconjunctivitis symptoms.

Clinically relevant abnormalities detected on physical examination.

History of severe drug allergy, severe angioedema or anaphylactic reaction to food.

Phase II HDM-SPIRE Safety and Efficacy Study