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The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery
Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response. Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane. To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well. Secondarily, kidney protection effect of propofol over desflurane will be compared.
Age
20 - 70 years
Sex
MALE
Healthy Volunteers
No
Yonsei University, Gangnam Severance Hospital
Seoul, South Korea
Start Date
May 1, 2014
Primary Completion Date
February 1, 2015
Completion Date
February 1, 2015
Last Updated
July 29, 2015
50
ACTUAL participants
propofol
DRUG
Desflurane
DRUG
Lead Sponsor
Yonsei University
NCT04550494
NCT06842498
Data Source & Attribution
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