PXVX0200 (CVD103-HgR) vs Shanchol in Mali

Inclusion Criteria

• •Able to understand the study and give consent (either written or through a process that involves audio tapes explaining all aspects of the study and the consent form in local languages \[Bambara and French\] followed by making a mark and signature by a literate witness)
• •Healthy men or women, age 18 to 45 years (inclusive) without significant medical history
• •Women of child-bearing potential must have negative urine pregnancy test at baseline, prior to vaccination. They must also be willing to use adequate birth control for the duration of the 28-day study and have additional pregnancy tests if indicated. Effective methods of birth control for this study include abstinence, intrauterine device (IUD), oral or depot contraceptive, or barrier plus spermicide
• •Willingness to remain in the study area until at least 42 days after receipt of the first vaccine dose