Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Duke University
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
male or female patients with clinical diagnoses of schizophrenia or schizo-affective disorder
between 18 and 60 years of age
patients whose treating clinicians have recommended treatment with clozapine (and the patients have agreed and provided signed informed consent for treatment with clozapine)
You may not be if
patients who have contraindications to metformin use, such as:
* a diagnosis of congestive heart failure
* renal impairment (serum creatinine \> 1.5 in males; \> 1.4 in females)
* hepatic disease (AST or ALT \> 2.0 times upper limit of normal (ULN)
* positive hepatitis B surface antigen or hepatitis C antibody
* total bilirubin\>1.2x ULN; majority conjugated
* metabolic acidosis (serum CO2 \< lower limit of normal),
* known hypersensitivity to metformin,
* recent (in the past 30 days) or scheduled radiological studies involving iodinated contrast material
* alcohol abuse/dependence within the past month
* concurrent treatment with drugs that are known to increase metformin blood levels including furosemide, nifedipine, and cationic drugs including cimetidine, amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim, and vancomycin
patients with blood dyscrasias that could be worsened by added fish oil
women who are pregnant or breastfeeding
Clareo Health | Effects of Metformin and Fish Oil on Treatment With Clozapine
