A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Repeat Doses of RV1729 for 28 Days in Patients With COPD

Exclusion Criteria

• •A history of life-threatening COPD including respiratory arrest, intensive care unit admission and/or requiring intubation.
• •A history of more than one hospitalisation for COPD in the 2 years before Screening.
• •Evidence of cor pulmonale, clinically significant pulmonary hypertension or chronic use of oxygen.
• •Upper or lower respiratory tract infection, including exacerbation of COPD, requiring augmentation of therapy within 6 weeks of Screening.
• •Other respiratory disorders: subjects with a history of asthma, active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis or other chronic pulmonary diseases.
• •A chest X-ray at Screening (or within 6 months prior to the Screening visit) showing abnormalities, which in the opinion of the Investigator are clinically significant and unrelated to COPD.
• •A history of chronic disease including, but not limited to, unstable or uncontrolled hypertension (or been diagnosed with hypertension in the 6 months before Screening), sleep apnoea, cardiovascular, endocrine, neurological, hepatic, gastrointestinal, renal, haematological, urological, immunological or ophthalmic diseases that the Investigator believes are clinically significant e.g., unstable and could impact subject safety by participation in the study.
• •Previous lung resection or lung reduction surgery.
• •Vital sign assessments outside the following ranges: for inclusion blood pressure (after the subject is supine for 10 minutes) must be between 100 and 160 mmHg systolic, inclusive, and between 55 and 100 mmHg diastolic; heart rate must be between 40-100 bpm. These criteria must be met at Screening, Day -1 and pre-dose on Day 1.
• •Have a clinical abnormality or laboratory parameters outside the reference range at Screening or Day -1.
• •Liver function test results (ALT, aspartate amino transferase and gamma glutamyl transferase) \>2 x ULN (upper limit of normal) at Screening or on Day -1.
• •Chronic liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
• •Positive test for human immunodeficiency virus (HIV) 1 and 2 antibodies, hepatitis B virus (HBV) infection or hepatitis C antibodies.
• •Unable or unwilling to undergo multiple venepuncture procedures or the subject has poor access to veins suitable for cannulation.
• •If a woman, has a positive serum pregnancy test at Screening.
• •Definite or suspected history of drug or alcohol abuse within the previous 5 years.
• •Positive test for alcohol or drugs of abuse, including cannabinoids, alcohol, opiates, cocaine, amphetamines, benzodiazepines or barbiturates at Screening or on Day -1 or Day 1.
• •History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of \>21 units for males, or \>14 units for females.
• •History of clinically significant allergies that, in the opinion of the Investigator would contraindicate their participation.
• •Known allergy to the study drug or any of the excipients of the formulation or has previously been exposed to RV1729.
• •Donated blood or blood products or had substantial loss of blood (more than 500 mL) within 3 months before the first administration of study drug or intention to donate blood or blood products during the study.
• •Received an experimental drug or used an experimental medical device within 3 months or within a period less than five times the drug's half-life, whichever is longer, before the first dose of the study drug is scheduled.
• •Requires routine treatment for COPD using one (or more) of the therapies listed in the protocol within the 6 weeks before Screening.
• •A disclosed history or one known to the Investigator, of significant non-compliance in previous investigational studies or with prescribed medications.
• •Has had major surgery, (requiring general anaesthesia) within 6 weeks before the Screening visit, or will not have fully recovered from surgery, or has planned surgery from Screening through to the end of the study. Note: subjects with planned surgical procedures to be conducted under local anaesthesia may participate.
• •Employee of the Investigator or study centre, with direct involvement in the proposed study or other studies under the direction of that Investigator or study centre, as well as family members of the employees or the Investigator.
• •The subject is unable or unwilling to comply fully with the study protocol.
• •The subject is mentally or legally incapacitated.
• •Any other reason that the Investigator considers makes the subject unsuitable to participate.