Lead Sponsor

Medical University of Graz

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•25-hydroxyvitamin D levels below 30 ng/ml (75 nmol/L)
•Arterial hypertension defined according to recent guidelines as an average office blood pressure on at least two occasions of systolic ≥ 140 and/or diastolic ≥ 90 mmHg or a mean 24-hour ABP of systolic ≥ 125 and/or diastolic ≥ 80, or a home blood pressure of systolic ≥ 130 and/or diastolic ≥ 85 or ongoing antihypertensive treatment which was initiated due to arterial hypertension
•Age of ≥ 18 years
•Written informed consent.

•Hypercalcemia defined a serum calcium \>2.65 mmol/L
•Pregnancy or lactating women
•Drug intake as part of another clinical study
•Acute coronary syndrome or cerebrovascular events in the previous 2 weeks
•Glomerular filtration rate (GFR) according to the MDRD formula \< 15 ml/min/1.73m²
•Systolic 24-hour ABP \> 160 mm Hg or \< 120 mm Hg
•Diastolic 24-hour ABP \> 100 mm Hg
•Change of antihypertensive treatment (drugs and/or lifestyle) in the previous 4 weeks or planned changes of antihypertensive treatment during the study
•Any disease with an estimated life expectancy below 1 year
•Any clinically significant acute disease requiring drug treatment
•Chemotherapy or radiation therapy during the study
•Regular intake of more than 880 International Units (IU) vitamin D per day in the last four weeks before study entry or during the study