1. Consent not provided

2. Age less than 18 or greater than 89 years old on the day of ICU admission

3. Not admitted to ICU

4. Clinical cultures or serologies not obtained

5. Subject has been admitted to study hospital (or transferring facility) for ≥ 24 hours

6. Elective cardiac surgery patients with an expected duration in ICU of less than 24 hours.

7. Patients on non-prophylactic antibiotics for more than 24 hours prior to ICU admission

8. Delay of \>24 hours between trial enrollment and sample draw time

9. Ethnic/racial category has completed enrollment.

VENUS: Septic Gene Expression Using SeptiCyte