Seizure disorder

Other organic central nervous system disease

Subjects whose headaches are other than migraine, such as a result of traumatic head or neck injury

Evidence of alcohol, drug or substance abuse within the previous year

Subjects with intracardiac thrombus or tumor

Subjects who have an acute or recent (within 6 months) myocardial infarction or unstable angina

Subjects with left ventricular aneurysm or akinesis

Subjects with atrial fibrillation/atrial flutter (chronic or intermittent)

Subjects with another source of right to left shunt identified at baseline, including an atrial septal defect and/or fenestrated septum

Subjects with contraindication to aspirin or Clopidogrel therapy

Pregnant or desire to become pregnant within the next year

Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine