Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.

Exclusion Criteria

• •Currently on Nicotine Replacement Therapy (NRT) or smoking cessation drugs (e.g., Zyban, Chantix, etc.) or undergoing behavioral smoking cessation interventions
• •Cognitive or functional disability, diagnosed according to DSM-IV-TR criteria.
• •Active psychiatric disorder according to DSM IV (Axis I and Axis II) criteria within the last year.
• •Current alcohol or other substance abuse or dependence.
• •Alcohol or other substance abuse or dependence during the last 12 months before recruitment.
• •Subject is smoking any other form of tobacco or other substances.
• •Subject is taking psychotropic medications on a regular basis.
• •Subjects with a high risk for severe violence or suicidality as assessed during the screening interview.
• •Subjects who suffer from an unstable physical disease such as high blood pressure (\>150 mmHg systolic / diastolic \> 110 mmHg) or acute, unstable cardiac disease.
• •History of epilepsy or seizure (EXCEPT those therapeutically induced by ECT).
• •Increased risk of seizure for any reason, including prior diagnosis of increased intracranial pressure (such as after large infarctions or trauma), or history of significant head injury or trauma with loss of consciousness for \> 5 minutes.
• •History of any metal in the head (outside the mouth).
• •Metallic particles in the eye, implanted cardiac pacemaker or any intracardiac lines, implanted neurostimulators, intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or implanted medical pumps.
• •Individuals with a significant neurological disorder or insult including, but not limited to:
• •* Any condition likely to be associated with increased intracranial pressure
• •* Space occupying brain lesion
• •* History of cerebrovascular accident
• •* Transient ischemic attack within two years
• •* Cerebral aneurysm
• •* Dementia
• •* Mini Mental State Exam score of less than or equal to 24
• •* Parkinson's disease
• •* Huntington's chorea
• •* Multiple sclerosis
• •Subjects suffering from frequent and severe migraine headaches.
• •Subjects suffering from significant hearing loss.
• •Subjects taking pro-convulsant medications (e.g., antidepressants or antipsychotic medications).
• •Previous treatment with TMS.
• •Subjects who cannot communicate reliably with the investigator or who are not likely to cope with the requirements of the experiment.
• •Participation in a clinical trial within the last 30 days before the beginning of this clinical trial or similar participation in another clinical trial.
• •Known or suspected pregnancy or lactation.
• •Women of childbearing potential and not using a medically accepted form of contraception when engaging in sexual intercourse.