Lead Sponsor

University of Pittsburgh

Age

21 - 69 years

Sex

ALL

Healthy Volunteers

Yes

•Age 21-69 years-old;
•BMI 28-40;
•Presence of at least one of the following markers of insulin resistance: a) fasting hyperinsulinemia (\>7 uU/ml by ultrasensitive insulin assay); impaired fasting glucose (100-125 mg/dl); prior history of impaired glucose tolerance provided by the participant; history of previous gestational diabetes; history of PCOS; waist circumference \>40" (men) or \>35" (women) (cut-offs from ATP-III criteria for metabolic syndrome).

•Pregnancy, or unable/unwilling to avoid pregnancy during the study;
•Unstable cardiopulmonary disease, hepatitis, liver dysfunction, renal insufficiency, or any other medical condition affecting glucose metabolism or safety during the study;
•Diabetes;
•Medications that affect glucose metabolism: (e.g. systemic glucocorticoids, antipsychotics);
•History of hypersensitivity to local lidocaine, similar anesthetics, or HCQ;
•History of G6PDH deficiency;
•History of retinopathy;
•Weight instability (\>3Kg of weight change in the past three months);
•Bariatric surgery in the last two years, intention to lose weight or engage in exercise regimen during study;
•Alcohol intake \>1 drink/day (averaged);
•Hemoglobin \<10g%