Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hywel Dda Health Board
Age
50–80
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
COPD group - 15 Participants who have been diagnosed with any severity of COPD (according to BTS criteria, i.e. \>10 pack-year smoking history and post-bronchodilator spirometry FEV1/FVC ratio \<0.70 and FEV\<80%) and have completed at least 12 from 18 sessions of a pulmonary rehabilitation programme.
Age 50-80 years.
Current non-smoker.
Control group - 15 Participants who will act as Controls, without COPD or cardiovascular disease
Age 50-80 years (ideally of similar gender distribution)
Current non-smoker.
Spirometry: FEV1/FVC\>0.7 and FEV\>80% predicted
You may not be if
Known asthma or allergic rhinitis or other respiratory disease (bronchiectasis, pulmonary fibrosis).
A change in any medications within 4 weeks or during the study.
Require domiciliary oxygen.
Acute exacerbation of COPD within 4 weeks of study entry.
Any infection or illness within 4 weeks of study entry.
Other active inflammatory conditions e.g. rheumatoid arthritis, cancer, unstable cardiac conditions.
Receiving oral steroids or other immunomodulating drugs.
Currently undergoing exercise training (including Pulmonary Rehabilitation).
Any previous cardiovascular contraindications to exercise (e.g. unstable angina).
Inability to complete the 6MWT due to physical or mental impairment.
Exhaled CO\>10ppm or smoked any cigarettes within 6 months.
Inability or unwillingness to sign informed consent.
