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WITHDRAWNNCT02123147

Examining the Immunological Process of Autoimmune Patients

Sjögren's syndrome (SjS) is an autoimmune disease characterized primarily by exocrine gland dysfunction, specifically of the salivary and lacrimal glands, resulting in dry mouth and dry eyes symptoms....

Lead sponsor: University of Florida•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Florida

Blood from patient and healthy controls will be collected once every 3-6 months. White blood cells from blood samples will be separated. Tests will be done to see which substances these cells make. Using sequencing techniques, the investigators will determine the genetic code of the receptors expressed on these cells. The investigators plan to test how these cells change over the period of at least 3 years at different visits. In addition, the investigators will check how these changes relate to patients' general medical history relevant to autoimmune disease, lab results and physical examinations and exams pertinent to the diagnosis of autoimmune disease, and psychosocial data.

Age

9 - 21 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Primary Sjogren's syndrome patients: primary Sjogren's syndrome patients who meet the revised criteria for SjS diagnosis by the American-European Consensus Group.
•Secondary Sjogren's syndrome patients: secondary Sjogren's syndrome patients who meet the criteria for primary Sjogren's syndrome in association with other autoimmune diseases such as systemic lupus erythematosus , dermatomyositis, scleroderma, idiopathic arthritis, mixed connective tissue disease, etc.
•Subjects who does not have history of autoimmune diseases.

Exclusion Criteria

•Pregnant women.
•Patients with history of lymphoma or malignancy.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 8, 2017Terms

Trial snapshot

StatusWITHDRAWN

Phase—

Enrollment—

Start dateJul 2014

Last updatedAug 8, 2017

Condition

Sjogren's Syndrome Autoimmune Diseases Dry Eyes Dry Mouth

Locations shown

University of Florida

Gainesville, Florida

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 8, 2017Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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