Lead Sponsor

Akros Pharma Inc.

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

•Healthy Subject Cohorts:
•Healthy male or female subjects
•Age 18 to 50 Years (inclusive)
•Body Mass Index (BMI) between 19.0 and 31.0 kg/m2 (inclusive)
•Type 2 Diabetic Subject Cohorts:
•Male or female Type 2 diabetic subjects who are currently being treated with a stable dose of metformin
•Age 18 to 65 Years (inclusive)
•BMI between 25.0 and 40.0 kg/m2 (inclusive)
•Have a glycosylated hemoglobin (HbA1c) of \>7.0% to ≤9.5%
•Have a fasting plasma glucose (FPG) \<240 mg/dL

•Healthy Subject Cohorts:
•Known clinically relevant history or presence of significant respiratory, gastrointestinal, renal, hepatic, hematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, metabolic and dermatological or connective tissue disease
•Subjects with a systolic blood pressure \>140 mmHg and/or diastolic blood pressure \>90 mmHg
•Type 2 Diabetic Subject Cohorts:
•Subjects with a known medical history or presence of type 1 diabetes mellitus
•Subjects with known medical history of acute metabolic diabetic complications
•Subjects with uncontrolled hypertension (systolic blood pressure \>150 mmHg and/or diastolic blood pressure \>95 mmHg